Digitization will have a decisive impact on the socio-technical systems of tomorrow: On the one hand, the complexity of technical systems is increasing; on the other hand, the associated production systems and the future organization of work are also changing. Mastering complexity requires a cross-disciplinary approach. A system-oriented and model-based development system is required that encompasses all areas of strategic product planning and production system development, including the associated design of work, the associated services and consideration of the entire value creation system. Advanced Systems Engineering (ASE) offers new solution approaches for this. There is a great need for research in this area with regard to engineering in the environment of digitization and artificial intelligence (AI) and the continuous mapping of the product and service life cycle. In addition, the internal and cross-company organization must be researched and cross-disciplinary development methods for the interaction of the players involved must be created. Overarching measures are essential to ensure that the project results have the necessary impact to give Germany as an innovation location a decisive edge over its international competitors. In this way, industrial solutions obtained can be dovetailed, refined and prioritized with a view to the future. Previous work on development methods has not gone far enough in this respect. For the task of such an accompanying research the scientific project AdWiSE is created.